Elimination of plasmids by new 4-quinolones
نویسندگان
چکیده
منابع مشابه
Elimination of plasmids by new 4-quinolones.
Nalidixic acid and six of the new 4-quinolones eliminated F'lac and various native R plasmids from Escherichia coli at one half or one quarter the MIC. Four of eight plasmids tested were cured by all derivatives, with frequencies from 10 to 98%. Quinolones did not eliminate all plasmids that were cured by novobiocin, and vice versa.
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The bactericidal activity of two new 4-quinolones, DU-6859a and DV-7751a, was investigated against strains of Escherichia coli, Staphylococcus aureus, S. epidermidis, Streptococcus pneumoniae and Enterococcus faecalis. DU-6859a and DV-7751a were more bactericidal than any 4-quinolone tested previously. Furthermore, DU-6859a was unique among 4-quinolones in being able to kill Ent. faecalis after...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1985
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.28.5.700